KABUL, Afghanistan – U.S.-led troops attacked a compound where Taliban leaders were meeting and killed 30 militants, American and Afghan military officials said Friday, but the Interior Ministry said a large number of civilians died. The U.S. said it would investigate.

The coalition was striking back against insurgents opposed to the Western-backed government of President Hamid Karzai who have stepped up attacks on foreign and Afghan troops.

The coalition said its troops called in airstrikes on the compound in the Shindand district of western Herat province Thursday.

Some 30 militants were killed and five others were detained, a spokesman, 1st Lt. Nathan Perry, said. The troops found a haul of weapons and ammunition inside the compound, he said.

Afghan officials issued contradictory statements about what had happened and it was not immediately clear why they offered such differing accounts.

An Afghan Defense Ministry spokesman, Gen. Mohammad Zaher Azimi, confirmed the clash but said five of the 30 dead were civilians.

However, the Afghan Interior Ministry claimed U.S. coalition bombs killed 76 civilians, including 19 women and 50 children under the age of 15. The ministry called the bombing a “mistake.”

A U.S. military spokeswoman, Lt. Col. Rumi Nielson-Green, said that a thorough assessment was done after the battle and that the coalition knew it killed 30 militants, including a high-ranking Taliban leader.

“We stand by our account and our reports and what we know and I can't reconcile why (the Interior Ministry) would have a different figure,” Nielson-Green said.

Later, however, the U.S. military command issued a statement saying it was investigating the claims that civilians were killed.

“All allegations of civilian casualties are taken very seriously. Coalition forces make every effort to prevent the injury or loss of innocent lives,” the statement said.

The operation was launched after an intelligence report that a Taliban commander, Mullah Siddiq, was inside the compound presiding over a meeting of militants, Azimi said. Siddiq was one of those killed during the raid, Azimi said.

It was impossible to independently verify the claims made after the airstrikes in the remote district far from the Afghan capital, Kabul.

A roadside bomb in the country's east, meanwhile, killed a U.S. coalition service member on Friday, the U.S. military said in a statement. The coalition did not provide other details on the incident or the victim's nationality.

Another roadside blast Friday hit an Italian army's armored vehicle some 12 miles north of Kabul, wounding three Italian soldiers Friday, the Italian Defense Ministry said.

Separately, Afghan and international troops clashed Thursday with militants in Khas Uruzgan district of Uruzgan province, killing 11 militants, said provincial police Chief Juma Gul Himat.

Three Afghan troops were wounded in the fight, Himat said. Authorities recovered the bodies of the dead militants, he said.

While most of Afghanistan's violence affects the southern and eastern regions that border Pakistan, militants have also been active in western areas bordering Iran.

In another clash Thursday involving airstrikes, the U.S.-led coalition said its forces killed “multiple militants” in the northern Kapisa province.

The operation in Tagab district targeted a Taliban commander involved in weapons smuggling and suicide attacks against Afghan and foreign troops, the coalition said.

Tagab is close to where militants killed 10 French troops on Tuesday in the deadliest ground attack on foreign troops since the Taliban were ousted from power in 2001.

More than 3,400 people – mostly militants – have been killed in insurgency-related violence this year, according to figures from Western and Afghan officials.

Associated Press writers Fisnik Abrashi in Kabul and Noor Khan in Kandahar contributed to this report.